Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.

Development (Cambridge, England) - 1 Aug 2010

Sun Pei, Quan Zhenghui, Zhang Bodi, Wu Tuoqi, Xi Rongwen

Abstract excerpt

Tuberous sclerosis complex human disease gene products TSC1 and TSC2 form a functional complex that negatively regulates target of rapamycin (TOR), an evolutionarily conserved kinase that plays a central role in cell growth and metabolism. Here, we describe a novel role of TSC1/2 in controlling stem cell maintenance. We show that in the Drosophila ovary, disruption of either the Tsc1 or Tsc2 gene in germline stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Germ Cells

Share to Intracellular Signaling Peptides and Proteins

Share to Microscopy, Fluorescence

Share to Sirolimus

Share to Stem Cells

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 20573703
DOI: 10.1242/dev.051466

Genes

GSC
TSC1
TSC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.PMID 20573703Read ↗

Stem cells commit to differentiation following multiple induction events in the Drosophila testisSemantic proximity Read ↗

Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells.Semantic proximity Read ↗

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.Semantic proximity Read ↗

A transitory signaling center controls timing of primordial germ cell differentiationSemantic proximity Read ↗

Nanos maintains germline stem cell self-renewal by preventing differentiation.Semantic proximity Read ↗

Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche.Semantic proximity Read ↗

Autophagy is dispensable in germline stem cells but is required in the cap cells for their maintenance in the Drosophila ovarian nicheSemantic proximity Read ↗

THE TAO OF STEM CELLS IN THE GERMLINESemantic proximity Read ↗

The mTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell DormancySemantic proximity Read ↗

MYCBP interacts with Sakura and Otu and is essential for germline stem cell renewal and differentiation and oogenesisSemantic proximity Read ↗

Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling.Semantic proximity Read ↗

Niche cells regulate primordial germ cell quiescence in response to basement membrane signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.