Article
Characterization of various types of mast cells derived from model mice of familial gastrointestinal stromal tumors with KIT-Asp818Tyr mutation.
International journal of clinical and experimental pathology - 1 Jan 2015
Kajimoto Noriko, Nakai Norihiro, Ohkouchi Mizuka, Hashikura Yuka, Liu-Kimura Ning-Ning, Isozaki Koji, Hirota Seiichi
Abstract excerpt
Sporadic mast cell neoplasms and gastrointestinal stromal tumors (GISTs) often have various types of somatic gain-of-function mutations of the c-kit gene which encodes a receptor tyrosine kinase, KIT. Several types of germline gain-of-function mutations of the c-kit gene have been detected in families with multiple GISTs. All three types of model mice for the familial GISTs with germline c-kit gene mutations at...
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