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Article

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.

Blood - 10 Feb 2011

Gerbaulet Alexander, Wickenhauser Claudia, Scholten Julia, Peschke Katrin, Drube Sebastian, Horny Hans-Peter, Kamradt Thomas, Naumann Ronald, Müller Werner, Krieg Thomas, Waskow Claudia, Hartmann Karin, Roers Axel

Abstract excerpt

Signaling through the receptor tyrosine kinase kit controls proliferation and differentiation of hematopoietic precursor cells and mast cells. Somatic point mutations of the receptor that constitutively activate kit signaling are associated with mastocytosis and various hematopoietic malignancies. We generated a Cre/loxP-based bacterial artificial chromosome transgenic mouse model that allows conditional...

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Source

Identifiers

PMID: 21148330
DOI: 10.1182/blood-2008-11-189605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.PMID 21148330Read ↗

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