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Article

Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM).

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Muzumdar Mandar Deepak, Luo Liqun, Zong Hui

Abstract excerpt

The initiation and progression of many human cancers involve either somatic activation of protooncogenes or inactivation of tumor-suppressor genes (TSGs) in sporadic cells. Although sporadic gain-of-function of protooncogenes has been successfully modeled in mice [e.g., Johnson L, Mercer K, Green...

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Identifiers

PMID: 17360552
DOI: 10.1073/pnas.0606491104
PMCID: PMC1810340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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