Article
Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2017
Bosbach Benedikt, Rossi Ferdinand, Yozgat Yasemin, Loo Jennifer, Zhang Jennifer Q, Berrozpe Georgina, Warpinski Katherine, Ehlers Imke, Veach Darren, Kwok Andrew, Manova Katia, Antonescu Cristina R, DeMatteo Ronald P, Besmer Peter
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the requirement of different signal transduction pathways emanating from KIT for tumorigenesis, the oncogenic KitV558Δ mutation was combined with point mutations abrogating specific phosphorylation sites on KIT. Compared with single-mutant KitV558Δ/+ mice,...
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