Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation.

Developmental biology - 15 Jul 2009

John George B, Shidler Meredith J, Besmer Peter, Castrillon Diego H

Abstract excerpt

In mammals, primordial follicles are generated early in life and remain dormant for prolonged intervals. Their growth resumes via a process known as primordial follicle activation. Recent genetic studies have demonstrated that phosphoinositide 3-kinase (PI3K) is the essential signaling pathway controlling this process throughout life, acting via Akt to regulate nucleocytoplasmic shuttling of Foxo3, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ovarian Follicle

Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-kit

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19447101
DOI: 10.1016/j.ydbio.2009.05.546
PMCID: PMC2726617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation.PMID 19447101Read ↗

Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthoodSemantic proximity Read ↗

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development.Semantic proximity Read ↗

KIT signaling regulates primordial follicle formation in the neonatal mouse ovarySemantic proximity Read ↗

Lhx8 regulates primordial follicle activation and postnatal folliculogenesisSemantic proximity Read ↗

Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in miceSemantic proximity Read ↗

Regulation of primordial follicle assembly and developmentSemantic proximity Read ↗

Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functionsSemantic proximity Read ↗

Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling.Semantic proximity Read ↗

Advances in human primordial follicle activation and premature ovarian insufficiencySemantic proximity Read ↗

In Vitro Activation Early Follicles: From the Basic Science to the Clinical PerspectivesSemantic proximity Read ↗

Insights into Primary Ovarian Insufficiency through Genetically Engineered Mouse ModelsSemantic proximity Read ↗

Roles of KIT and KIT LIGAND in ovarian functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.