Article
The genetic regulation of the induction of experimental SLE.
Immunology - 1 Feb 1990
Mendlovic S, Brocke S, Fricke H, Shoenfeld Y, Bakimer R, Mozes E
Abstract excerpt
We have recently reported the induction of systemic lupus erythematosus (SLE) in C3H.SW female mice by their immunization with a human monoclonal anti-DNA antibody that bears a common idiotype termed 16/6 Id. In the present study, the ability to induce experimental SLE in seven inbred mouse strains by immunization with the 16/6 Id was examined. Two out of the seven strains failed to develop the disease. These two...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Antibodies, Antinuclear
- Antibodies, Monoclonal
- Genetic Predisposition to Disease
- Immunization
- Immunoglobulin Idiotypes
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred Strains