Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.

doi:10.1016/s1074-7613(00)80088-6

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Article

Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.

Immunity - 1 Aug 1999

Morel L, Tian X H, Croker B P, Wakeland E K

Abstract excerpt

Sle1 and Sle3 are NZW-derived loci that mediate lupus nephritis on a C57BL/6 background. The absence of severe autoimmunity in NZW suggests that the NZW genome suppresses these genes. (B6.NZMc1[Sle1] x NZW)F1 hybrids develop severe humoral autoimmunity and fatal lupus nephritis, indicating that suppression of Sle1 from NZW is recessive. Linkage analysis identified four epistatic modifiers, Sles1-4, whose...

Topics

Alleles
Animals
Autoimmunity
Chromosome Mapping
Crosses, Genetic
Female
Genetic Linkage
Genetic Predisposition to Disease
H-2 Antigens
Lupus Erythematosus, Systemic
Lupus Nephritis
Male
Mice
Mice, Inbred C57BL
Mice, Inbred NZB

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Open in PubMed

Identifiers

PMID: 10485648
DOI: 10.1016/s1074-7613(00)80088-6

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