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Article

IL-1 beta-deficient mice are resistant to induction of experimental SLE.

European cytokine network - 1 Jun 2006

Voronov Elena, Dayan Molly, Zinger Heidy, Gayvoronsky Lubov, Lin Jian-Ping, Iwakura Yoichiro, Apte Ron N, Mozes Edna

Abstract excerpt

IL-1 is one of the most pleiotropic pro-inflammatory and immunostimulatory cytokines. Overproduction of IL-1 has been shown to be involved in the pathogenicity of various autoimmune inflammatory diseases, including systemic lupus erythematosus (SLE). However, the different contributions that the IL-1 agonistic molecules make in their in vivo native milieu, IL-1beta which is mainly secreted against IL-1alpha which...

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PMID: 16840029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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