Article
IL-1 beta-deficient mice are resistant to induction of experimental SLE.
European cytokine network - 1 Jun 2006
Voronov Elena, Dayan Molly, Zinger Heidy, Gayvoronsky Lubov, Lin Jian-Ping, Iwakura Yoichiro, Apte Ron N, Mozes Edna
Abstract excerpt
IL-1 is one of the most pleiotropic pro-inflammatory and immunostimulatory cytokines. Overproduction of IL-1 has been shown to be involved in the pathogenicity of various autoimmune inflammatory diseases, including systemic lupus erythematosus (SLE). However, the different contributions that the IL-1 agonistic molecules make in their in vivo native milieu, IL-1beta which is mainly secreted against IL-1alpha which...
Topics
- Animals
- Antibodies
- Disease Models, Animal
- Female
- Genetic Predisposition to Disease
- Immunity, Innate
- Interleukin-1
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred BALB C
- Mice, Knockout