Article
Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background.
Arthritis and rheumatism - 1 Oct 2011
Sato-Hayashizaki Aya, Ohtsuji Mareki, Lin Qingshun, Hou Rong, Ohtsuji Naomi, Nishikawa Keiko, Tsurui Hiromichi, Sudo Katsuko, Ono Masao, Izui Shozo, Shirai Toshikazu, Takai Toshiyuki, Nishimura Hiroyuki, Hirose Sachiko
Abstract excerpt
OBJECTIVE: Fcγ receptor type IIb (FcγRIIb) is a major negative regulator of B cells, and the lack of FcγRIIb expression has been reported to induce systemic lupus erythematosus (SLE) in mice of the C57BL/6 (B6) genetic background. The 129 strain-derived Sle16 locus on the telomeric region of chromosome 1 including polymorphic Fcgr2b confers the predisposition to systemic autoimmunity when present on the B6...
Topics
- Animals
- Arthritis, Rheumatoid
- Autoimmunity
- Genetic Loci
- Genetic Predisposition to Disease
- Mice
- Mice, Congenic
- Mice, Inbred C57BL
- Mice, Knockout