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Article

Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

Arthritis and rheumatism - 1 Jul 2008

Fossati-Jimack Liliane, Cortes-Hernandez Josefina, Norsworthy Peter J, Cook H Terence, Walport Mark J, Botto Marina

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus is a multifactorial disease with a strong genetic component. Previous studies have shown that a 129-derived chromosome 1 interval (Sle16) on the C57BL/6 (B6) background is sufficient to induce humoral autoimmunity. The aim of the present study was to elucidate the mechanisms by which this locus contributes to the loss of peripheral tolerance. METHODS: Anti-single-stranded...

Topics

Animals
Autoantibodies
Autoimmunity
B-Lymphocytes
Chromosomes, Human, Pair 1
DNA, Single-Stranded
Humans
Immunoglobulin Class Switching
Immunoglobulin G
Immunoglobulin M
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Phenotype

Source

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Identifiers

PMID: 18576325
DOI: 10.1002/art.23553
PMCID: PMC2658014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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