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Article

Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus

2 Jul 1993

Abstract excerpt

Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast,...

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Identifiers

PMID: 8316860
DOI: 10.1126/science.8316860

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Source receipt: pubmed, retrieved 7 Sept 2026.

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