Article
Genetic regulation of anti-erythrocyte autoantibodies and splenomegaly in autoimmune hemolytic anemia-prone new zealand black mice.
International immunology - 1 Jan 2000
Ochiai K, Ozaki S, Tanino A, Watanabe S, Ueno T, Mitsui K, Toei J, Inada Y, Hirose S, Shirai T, Nishimura H
Abstract excerpt
New Zealand Black (NZB) mice spontaneously produce anti-erythrocyte autoantibodies (AEA) in association with splenomegaly, thus serving as a model for autoimmune hemolytic anemia. Although these autoimmune traits are inherited as a dominant fashion, expression in F(1) hybrids of NZB and most non-New Zealand strains is suppressed due to the contribution of wild-type modifying genes present in the latter strains....
Topics
- Anemia, Hemolytic, Autoimmune
- Animals
- Autoantibodies
- Autoimmunity
- Chromosome Mapping
- Crosses, Genetic
- Disease Models, Animal
- Erythrocytes
- Genetic Predisposition to Disease
- Genotype
- Lod Score
- Mice
- Mice, Inbred C57BL