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Article

Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2002

Sobel Eric S, Morel Laurence, Baert Raquel, Mohan Chandra, Schiffenbauer Joel, Wakeland Edward K

Abstract excerpt

On the non-autoimmune C57BL/6 (B6) background, the chromosome 7-derived lupus susceptibility loci Sle3 and Sle5 have been shown to mediate an elevated CD4:CD8 ratio with an increase in activated CD4(+) T cells, decreased susceptibility to apoptosis, and a break in humoral tolerance. Development of subcongenic strains has subsequently shown that the elevated CD4:CD8 ratio is due to Sle3 but that both loci...

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PMID: 12244205
DOI: 10.4049/jimmunol.169.7.4025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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