Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody family.

doi:10.1093/intimm/2.10.1003

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Article

Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody family.

International immunology - 1 Jan 1990

Ghatak S, O'Keefe T L, Imanishi-Kari T, Datta S K

Abstract excerpt

Autoimmune NZB mice rarely develop nephritis, but the SNF1, progeny of Crosses between NZB and the normal SWR strain uniformly develop severe lupus nephritis, indicating that the normal SWR strain makes a genetic contribution to the development of nephritis. The SNF1 mice produce a select populat...

Topics

Alleles
Animals
Antibody Diversity
Autoantibodies
Base Sequence
Cloning, Molecular
DNA
Genes, Immunoglobulin
Hybridomas
Lupus Nephritis
Mice
Mice, Inbred Strains
Molecular Sequence Data
Restriction Mapping
Species Specificity

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