Article
Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody family.
International immunology - 1 Jan 1990
Ghatak S, O'Keefe T L, Imanishi-Kari T, Datta S K
Abstract excerpt
Autoimmune NZB mice rarely develop nephritis, but the SNF1, progeny of Crosses between NZB and the normal SWR strain uniformly develop severe lupus nephritis, indicating that the normal SWR strain makes a genetic contribution to the development of nephritis. The SNF1 mice produce a select population of cationic IgG anti-DNA autoantibodies that share a recurrent cross-reactive idiotype called Id564 and these...
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