Article
Lupus-prone strains vary in susceptibility to antibody-mediated end organ disease.
Genes and immunity - 1 Apr 2013
Xie C, Du Y, Kumar K, Li L, Han J, Liu K, Zhou X J, Mohan C
Abstract excerpt
Renal involvement is the major cause of morbidity and mortality in lupus. Besides autoantibodies, intrinsic renal factors may contribute to the susceptibility to lupus nephritis. To determine how different mouse strains that develop spontaneous lupus fare in their susceptibility to immune mediated nephritis, mice from six lupus-prone strains and two non-lupus control strains (B6 and BALB/c) were challenged with...
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