Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder.

doi:10.1111/j.1399-5618.2011.00897.x

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Article

Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder.

Bipolar disorders - 1 Feb 2011

Uemura Takuji, Green Marty, Corson Timothy W, Perova Tatiana, Li Peter P, Warsh Jerry J

Abstract excerpt

OBJECTIVES: Disrupted intracellular calcium (Ca(2+) ) homeostasis (ICH) related to mitochondrial and/or endoplasmic reticulum (ER) dysfunction has been implicated in bipolar disorder (BD). The anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2), encoded in a putative BD susceptibility locus, modulates ER-Ca(2+) dynamics. Recently, an intronic single-nucleotide polymorphism (SNP) in the Bcl-2 gene, rs956572, was...

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PMID: 21320251
DOI: 10.1111/j.1399-5618.2011.00897.x

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