Article
The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder.
Biological psychiatry - 15 Feb 2011
Machado-Vieira Rodrigo, Pivovarova Natalia B, Stanika Ruslan I, Yuan Peixiong, Wang Yun, Zhou Rulun, Zarate Carlos A, Drevets Wayne C, Brantner Christine A, Baum Amber, Laje Gonzalo, McMahon Francis J, Chen Guang, Du Jing, Manji Husseini K, Andrews S Brian
Abstract excerpt
BACKGROUND: Bipolar disorder (BPD) is characterized by altered intracellular calcium (Ca(2+)) homeostasis. Underlying mechanisms involve dysfunctions in endoplasmic reticulum (ER) and mitochondrial Ca(2+) handling, potentially mediated by B-cell lymphoma 2 (Bcl-2), a key protein that regulates Ca(2+) signaling by interacting directly with these organelles, and which has been implicated in the pathophysiology of...
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