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Article

Matrix stiffness in three-dimensional systems effects on the behavior of C3A cells.

Artificial organs - 1 Feb 2013

Huang Xiaobo, Hang Ruiqiang, Wang Xiaoguang, Lin Naiming, Zhang Xiangyu, Tang Bin

Abstract excerpt

The purpose of this study was to evaluate in vitro how the modulation of stiffness in a three-dimensional (3D) system independently influenced the behaviors of hepatocytes. Cells of a human hepatocyte cell line, C3A, which have been used in a clinically tested bioartificial liver support system, were conducted as cell models. Using a 3D system of "mechanically tunable" alginate hydrogels, matrix stiffness was...

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Identifiers

PMID: 23067437
DOI: 10.1111/j.1525-1594.2012.01546.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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