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Article

Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma.

Journal of translational medicine - 3 Dec 2022

Wei Jiayun, Yao Jia, Yang Chendong, Mao Yongcui, Zhu Dan, Xie Ye, Liu Pinyan, Yan Mengchao, Ren Longfei, Lin Yan, Zheng Qiuxia, Li Xun

Abstract excerpt

BACKGROUND: Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains unclear how the heterogeneous physical microenvironment affects stemness expression in cancer cells. Here, we aimed to evaluate matrix stiffness heterogeneity in hepatocellular carcinoma (HCC)...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36463272
DOI: 10.1186/s12967-022-03778-w
PMCID: PMC9719217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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