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Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental Arthritis

14 Oct 2012

Abstract excerpt

To investigate the role of Roquin, a RING-type ubiquitin ligase family member, we used transgenic mice with enforced Roquin expression in T cells, with collagen-induced arthritis (CIA). Wild-type (WT) and Roquin transgenic (Tg) mice were immunized with bovine type II collagen (CII). Arthritis severity was evaluated by clinical score; histopathologic CIA severity; proinflammatory and anti-inflammatory cytokine...

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PMID: 23066015
DOI: 10.1074/jbc.m112.374835

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Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental ArthritisPMID 23066015Read ↗

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