Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roquin--a multifunctional regulator of immune homeostasis.

Genes and immunity - 1 Mar 2016

Schaefer J S, Klein J R

Abstract excerpt

Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice. A single base-pair mutation in the Rc3h1 gene resulted in the manifestation of autoantibody production and sustained immunological inflammation characterized by excessive T follicular helper cell activation and formation of germinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Germinal Center
Share to Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inducible T-Cell Co-Stimulator Protein

Share to Lupus Erythematosus, Systemic

Share to Lymphocyte Activation

Share to Receptors, Tumor Necrosis Factor

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 26673963
DOI: 10.1038/gene.2015.58
PMCID: PMC4777649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roquin--a multifunctional regulator of immune homeostasis.PMID 26673963Read ↗

Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.Semantic proximity Read ↗

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.Semantic proximity Read ↗

Molecular control of Tfh-cell differentiation by Roquin family proteins.Semantic proximity Read ↗

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutationSemantic proximity Read ↗

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.Semantic proximity Read ↗

ROQUIN-1 binding to the transcriptome of T cells reveals conserved targets in the control of lymphopoiesisSemantic proximity Read ↗

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.Semantic proximity Read ↗

Roquin-dependent gene regulation in immune-mediated diseases and future therapiesSemantic proximity Read ↗

ROQUIN/RC3H1 Alterations Are Not Found in Angioimmunoblastic T-Cell LymphomaSemantic proximity Read ↗

<i>VCAM1</i>-expressing T cells and systemic autoimmunity in Regnase-1 deficiencySemantic proximity Read ↗

Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders.Semantic proximity Read ↗

Regnase-1, a ribonuclease involved in the regulation of immune responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.