Therapeutic Effect of Exogenous Truncated IK Protein in Inflammatory Arthritis.

Abstract excerpt

Inhibitor K562 (IK) protein was first isolated from the culture medium of K562, a leukemia cell line. It is known to be an inhibitory regulator of interferon-γ-induced major histocompatibility complex class (MHC) II expression. Previously, we found that transgenic (Tg) mice constitutively expressing truncated IK (tIK) showed reduced numbers of pathogenic Th1 and Th17 cells, which are known to be involved in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anti-Inflammatory Agents
• Share to Arthritis, Experimental