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Article

Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis.

Arthritis research & therapy - 10 Jan 2014

Tang Bo, Kim Seunghyun, Hammond Sarah, Cullins David L, Brand David D, Rosloniec Edward F, Stuart John M, Postlethwaite Arnold E, Kang Andrew H, Myers Linda K

Abstract excerpt

INTRODUCTION: T cells orchestrate joint inflammation in rheumatoid arthritis (RA), yet they are difficult to study due to the small numbers of antigen-specific cells. The goal of this study was to characterize a new humanized model of autoimmune arthritis and to describe the phenotypic and functional changes that occur in autoimmune T cells following the induction of pathological events. METHODS: We developed a...

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Source

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Identifiers

PMID: 24405551
DOI: 10.1186/ar4433
PMCID: PMC3978884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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