Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist.

doi:10.1002/1529-0131(199810)41:10<1798::AID-ART11>3.0.CO;2-L

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Article

Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist.

Arthritis and rheumatism - 1 Oct 1998

Ma Y, Thornton S, Boivin G P, Hirsh D, Hirsch R, Hirsch E

Abstract excerpt

OBJECTIVE: To determine the effect of overexpression or deletion of interleukin-1 receptor antagonist (IL-1Ra) in collagen-induced arthritis (CIA). METHODS: Mice overexpressing the IL-1Ra gene under the control of its endogenous promoter, mice lacking IL-1Ra, and normal littermate controls were i...

Topics

Animals
Antibody Formation
Arthritis, Experimental
B-Lymphocytes
Collagen
Genetic Predisposition to Disease
Immunity, Cellular
Immunization
Interleukin 1 Receptor Antagonist Protein
Mice
Mice, Transgenic
Promoter Regions, Genetic
RNA, Messenger
Sialoglycoproteins
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 9778220
DOI: 10.1002/1529-0131(199810)41:10<1798::AID-ART11>3.0.CO;2-L

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9778220-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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