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Article

Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist.

Arthritis and rheumatism - 1 Oct 1998

Ma Y, Thornton S, Boivin G P, Hirsh D, Hirsch R, Hirsch E

Abstract excerpt

OBJECTIVE: To determine the effect of overexpression or deletion of interleukin-1 receptor antagonist (IL-1Ra) in collagen-induced arthritis (CIA). METHODS: Mice overexpressing the IL-1Ra gene under the control of its endogenous promoter, mice lacking IL-1Ra, and normal littermate controls were immunized with bovine type II collagen (CII) and compared in terms of features of CIA. RESULTS: Mice overexpressing...

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Source

Identifiers

PMID: 9778220
DOI: 10.1002/1529-0131(199810)41:10<1798::AID-ART11>3.0.CO;2-L

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