Mammalian <i>Clock</i> Gene <i>Cryptochrome</i> Regulates Arthritis via Proinflammatory Cytokine TNF-α

Abstract excerpt

The mammalian clock genes, Period and Cryptochrome (Cry), regulate circadian rhythm. We show that circadian rhythmicity and rhythmic expression of Period in the nuclei of inflammatory synovial cells and spleen cells are disturbed in mouse models of experimental arthritis. Expressions of other clock genes, Bmal1 and Dbp, are also disturbed in spleen cells by arthritis induction. Deletion of Cry1 and Cry2 results...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Circadian rhythm and melatonin
• Share to Herbal Medicine Research Studies
• Share to Medicinal Plants and Bioactive Compounds