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Article

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.

Nature - 8 Nov 2007

Yu Di, Tan Andy Hee-Meng, Hu Xin, Athanasopoulos Vicki, Simpson Nicholas, Silva Diego G, Hutloff Andreas, Giles Keith M, Leedman Peter J, Lam Kong Peng, Goodnow Christopher C, Vinuesa Carola G

Abstract excerpt

Immune responses are normally targeted against microbial pathogens and not self-antigens by mechanisms that are only partly understood. Here we define a newly discovered pathway that prevents autoimmunity by limiting the levels on T lymphocytes of aco-stimulatory receptor, the inducible T-cell co...

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PMID: 18172933
DOI: 10.1038/nature06253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18172933-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.PMID 18172933Read ↗

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.Semantic proximity Read ↗

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Roquin-dependent gene regulation in immune-mediated diseases and future therapiesSemantic proximity Read ↗

Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.Semantic proximity Read ↗

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.Semantic proximity Read ↗

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutationSemantic proximity Read ↗

ROQUIN-1 binding to the transcriptome of T cells reveals conserved targets in the control of lymphopoiesisSemantic proximity Read ↗

The Transcription Factor RORα Preserves ILC3 Lineage Identity and Function during Chronic Intestinal InfectionSemantic proximity Read ↗

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