The non–major histocompatibility complex quantitative trait locus <i>Cia10</i> contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage

Abstract excerpt

OBJECTIVE: To construct rats congenic for the chromosome 2 arthritis-regulatory quantitative trait locus Cia10, originally identified in a (DA x ACI)F(2) intercross rat strain that had been assessed for collagen-induced arthritis (CIA), and to determine the effect of this congenic interval on arthritis severity, joint histologic structure, and cytokine transcription in rats with pristane-induced arthritis (PIA)....

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