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Article

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.

Immunity - 20 Feb 2009

Linterman Michelle A, Rigby Robert J, Wong Raphael, Silva Diego, Withers David, Anderson Graham, Verma Naresh K, Brink Robert, Hutloff Andreas, Goodnow Chris C, Vinuesa Carola G

Abstract excerpt

During evolutionary adaptation in the immune system, host defense is traded off against autoreactivity. Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costimulatory receptor, ICOS, which arose by gene duplicat...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19217324
DOI: 10.1016/j.immuni.2008.12.015

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19217324-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.PMID 19217324Read ↗

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