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Article

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.

Immunity - 20 Feb 2009

Linterman Michelle A, Rigby Robert J, Wong Raphael, Silva Diego, Withers David, Anderson Graham, Verma Naresh K, Brink Robert, Hutloff Andreas, Goodnow Chris C, Vinuesa Carola G

Abstract excerpt

During evolutionary adaptation in the immune system, host defense is traded off against autoreactivity. Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costimulatory receptor, ICOS, which arose by gene duplication, are critical for affinity maturation and memory antibody responses. ICOS ligand, unlike the pathogen-inducible...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19217324
DOI: 10.1016/j.immuni.2008.12.015

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.PMID 19217324Read ↗

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