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Article

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model.

International journal of molecular sciences - 7 Oct 2020

Yang Hsin-Han, Xu Yue-Xuan, Chen Jie-Yi, Harn Horng-Jyh, Chiou Tzyy-Wen

Abstract excerpt

The phenotypic switch of vascular smooth muscle cells (VSMCs) plays a pivotal role in the development of vascular disorders, such as atherosclerosis, stenosis and restenosis, after vascular intervention. In our previous study, n-butylidenephthalide (BP) was reported to have anti-proliferating and apoptotic effects on VSMCs. The purpose of the current study is to further investigate its role in platelet-derived...

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Source

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Identifiers

PMID: 33036484
DOI: 10.3390/ijms21197403
PMCID: PMC7582375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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