Article
Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors.
PloS one - 1 Jan 2012
Latifi Ardian, Luwor Rodney B, Bilandzic Maree, Nazaretian Simon, Stenvers Kaye, Pyman Jan, Zhu Hongjian, Thompson Erik W, Quinn Michael A, Findlay Jock K, Ahmed Nuzhat
Abstract excerpt
Tumor cells in ascites are a major source of disease recurrence in ovarian cancer patients. In an attempt to identify and profile the population of ascites cells obtained from ovarian cancer patients, a novel method was developed to separate adherent (AD) and non-adherent (NAD) cells in culture. Twenty-five patients were recruited to this study; 11 chemonaive (CN) and 14 chemoresistant (CR). AD cells from both CN...
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