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Article

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden.

Molecular cancer - 27 Mar 2013

Abubaker Khalid, Latifi Ardian, Luwor Rod, Nazaretian Simon, Zhu Hongjian, Quinn Michael A, Thompson Erik W, Findlay Jock K, Ahmed Nuzhat

Abstract excerpt

Over 80% of women diagnosed with advanced-stage ovarian cancer die as a result of disease recurrence due to failure of chemotherapy treatment. In this study, using two distinct ovarian cancer cell lines (epithelial OVCA 433 and mesenchymal HEY) we demonstrate enrichment in a population of cells with high expression of CSC markers at the protein and mRNA levels in response to cisplatin, paclitaxel and the...

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Share to Antigens, Surface
Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Endonucleases

Share to Neoplasms, Glandular and Epithelial

Share to Spheroids, Cellular

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Source

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Identifiers

PMID: 23537295
DOI: 10.1186/1476-4598-12-24
PMCID: PMC3668985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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