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Article

Aggressive serous epithelial ovarian cancer is potentially propagated by EpCAM+CD45+ phenotype.

Oncogene - 1 Apr 2018

Akhter Md Zahid, Sharawat Surender K, Kumar Vikash, Kochat Veena, Equbal Zaffar, Ramakrishnan Mallika, Kumar Umesh, Mathur Sandeep, Kumar Lalit, Mukhopadhyay Asok

Abstract excerpt

Epithelial ovarian carcinoma (EOC) patients often acquire resistance against common chemotherapeutic drugs like paclitaxel and cisplatin. The mechanism responsible for the same is ambiguous. We have identified a putative drug-resistant tumour cell phenotype (EpCAM+CD45+) in the ascitic fluid of EOC patients, which appears to originate from the primary tumour. These cells represent the major tumour burden and are...

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Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystadenocarcinoma, Serous

Share to Epithelial Cell Adhesion Molecule

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Source

Identifiers

PMID: 29379166
DOI: 10.1038/s41388-017-0106-y

Genes

ABCA1
BCL2
SIRT1

Provenance

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