Article
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance.
Cell cycle (Georgetown, Tex.) - 1 Jan 2009
Alvero Ayesha B, Chen Rui, Fu Han-Hsuan, Montagna Michele, Schwartz Peter E, Rutherford Thomas, Silasi Dan-Arin, Steffensen Karina D, Waldstrom Marianne, Visintin Irene, Mor Gil
Abstract excerpt
A major burden in the treatment of ovarian cancer is the high percentage of recurrence and chemoresistance. Cancer stem cells (CSCs) provide a reservoir of cells that can self-renew, can maintain the tumor by generating differentiated cells [non-stem cells (non-CSCs)] which make up the bulk of the tumor and may be the primary source of recurrence. We describe the characterization of human ovarian cancer stem...
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