Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing.

Development (Cambridge, England) - 1 Nov 2012

Obholzer Nikolaus, Swinburne Ian A, Schwab Evan, Nechiporuk Alex V, Nicolson Teresa, Megason Sean G

Abstract excerpt

Forward genetic screens in zebrafish have identified >9000 mutants, many of which are potential disease models. Most mutants remain molecularly uncharacterized because of the high cost, time and labor investment required for positional cloning. These costs limit the benefit of previous genetic screens and discourage future screens. Drastic improvements in DNA sequencing technology could dramatically improve the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deafness

Share to Ear, Inner

Share to Genetic Linkage

Share to Genome

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23052906
DOI: 10.1242/dev.083931
PMCID: PMC3478692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing.PMID 23052906Read ↗

Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing.Semantic proximity Read ↗

Fast homozygosity mapping and identification of a zebrafish ENU-induced mutation by whole-genome sequencing.Semantic proximity Read ↗

MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq.Semantic proximity Read ↗

A major zebrafish polymorphism resource for genetic mapping.Semantic proximity Read ↗

Phenotype to genotype: A new and rapid approach using whole-genome sequencing.Semantic proximity Read ↗

Mutation mapping and identification by whole-genome sequencing.Semantic proximity Read ↗

RNA-seq-based mapping and candidate identification of mutations from forward genetic screens.Semantic proximity Read ↗

Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish.Semantic proximity Read ↗

Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays.Semantic proximity Read ↗

Large-scale mapping of mutations affecting zebrafish development.Semantic proximity Read ↗

Efficient mutation identification in zebrafish by microarray capturing and next generation sequencing.Semantic proximity Read ↗

Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.