Article
A major zebrafish polymorphism resource for genetic mapping.
Genome biology - 1 Jan 2007
Bradley Kevin M, Elmore J Bradford, Breyer Joan P, Yaspan Brian L, Jessen Jason R, Knapik Ela W, Smith Jeffrey R
Abstract excerpt
We have identified 645,088 candidate polymorphisms in zebrafish and observe a single nucleotide polymorphism (SNP) validation rate of 71% to 86%, improving with polymorphism confidence score. Variant sites are non-random, with an excess of specific novel T- and A-rich motifs. We positioned half of the polymorphisms on zebrafish genetic and physical maps as a resource for positional cloning. We further demonstrate...
Topics
- Animals
- Chromosome Mapping
- Cloning, Molecular
- Genetic Linkage
- Genetic Markers
- Polymorphism, Single Nucleotide
- Zebrafish