Article
Phenotype to genotype: A new and rapid approach using whole-genome sequencing.
PLoS genetics - 1 Jul 2025
Feltes McKenna, Zimin Aleksey V, Angel Sofia, Pansari Nainika, Hensley Monica R, Anderson Jennifer L, Shen Meng-Chieh, Klemek Mackenzie, Shen Yi, Ginde Vighnesh S, Kozan Hannah, Le Nhan V, Truong Vivian P, Wilson Meredith H, Salzberg Steven L, Farber Steven A
Abstract excerpt
Forward genetic screening is a powerful approach to assign functions to genes and can be used to elucidate the many genes whose functions remain unknown. A key step in forward genetic screening is mapping: identification of the gene causing the phenotype. Existing mapping methods use a bioinformatic mapping-by-sequencing approach based on allelic frequency calculations that often identify large genomic regions...
Topics
- Zebrafish
- Animals
- Phenotype
- Whole Genome Sequencing
- Genotype
- Mutation
- Chromosome Mapping
- Algorithms
- Zebrafish Proteins
- Zea mays