Article
Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays.
Genome research - 1 Dec 2002
Stickney Heather L, Schmutz Jeremy, Woods Ian G, Holtzer Caleb C, Dickson Mark C, Kelly Peter D, Myers Richard M, Talbot William S
Abstract excerpt
Large-scale genetic screens in zebrafish have identified thousands of mutations in hundreds of essential genes. The genetic mapping of these mutations is necessary to link DNA sequences to the gene functions defined by mutant phenotypes. Here, we report two advances that will accelerate the mapping of zebrafish mutations: (1) The construction of a first generation single nucleotide polymorphism (SNP) map of the...
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