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Article

Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing.

Genetics - 1 Mar 2012

Bowen Margot E, Henke Katrin, Siegfried Kellee R, Warman Matthew L, Harris Matthew P

Abstract excerpt

The generation and analysis of mutants in zebrafish has been instrumental in defining the genetic regulation of vertebrate development, physiology, and disease. However, identifying the genetic changes that underlie mutant phenotypes remains a significant bottleneck in the analysis of mutants. Whole-genome sequencing has recently emerged as a fast and efficient approach for identifying mutations in nonvertebrate...

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Identifiers

PMID: 22174069
DOI: 10.1534/genetics.111.136069
PMCID: PMC3296239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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