Article
Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish.
Methods in cell biology - 1 Jan 2011
Clark Matthew D, Guryev Victor, Bruijn Ewart de, Nijman Isaac J, Tada Masazumi, Wilson Catherine, Deloukas Panos, Postlethwait John H, Cuppen Edwin, Stemple Derek L
Abstract excerpt
Despite considerable genetic and genomic resources the positional cloning of forward mutations remains a slow and manually intensive task, typically using gel based genotyping and sequential rounds of mapping. We have used the latest genetic resources and genotyping technologies to develop two commercially available SNP panels of thousands of markers that can be used to speed up positional cloning.
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