Article
Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.
Genes and immunity - 1 Dec 2012
Gyllenberg A, Asad S, Piehl F, Swanberg M, Padyukov L, Van Yserloo B, Rutledge E A, McNeney B, Graham J, Orho-Melander M, Lindholm E, Graff C, Forsell C, Akesson K, Landin-Olsson M, Carlsson A, Forsander G, Ivarsson S A, Larsson H, Lindblad B, Ludvigsson J, Marcus C, Lernmark A, Alfredsson L, Akesson K, Olsson T, Kockum I
Abstract excerpt
The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region in Scandinavian type 1 diabetes...
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