Article
Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility.
Tissue antigens - 1 Apr 2009
Dema B, Martínez A, Fernández-Arquero M, Maluenda C, Polanco I, Angeles Figueredo M, de la Concha E G, Urcelay E, Núñez C
Abstract excerpt
Celiac disease (CD) is a multifactorial disease characterized by intestinal inflammation after gluten exposure in genetically susceptible individuals. A strong influence of certain human leukocyte antigen (HLA) alleles (those coding the HLA-DQ2 and DQ8 heterodimers) is well established, but they cannot explain the overall genetic risk. CIITA could be a good candidate gene for CD because it is mainly...
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