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Article

Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates.

Human immunology - 1 Jul 2009

Douroudis Konstantinos, Laine Antti-Pekka, Heinonen Mirkka, Hermann Robert, Lipponen Kati, Veijola Riitta, Simell Olli, Knip Mikael, Uibo Raivo, Ilonen Jorma, Kisand Kalle

Abstract excerpt

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases. The aim of the current study was to assess the impact of CTLA-4 and ICOS genes on the susceptibility to type 1 diabetes among t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19376178
DOI: 10.1016/j.humimm.2009.04.023

Genes

ICOS
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19376178-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates.PMID 19376178Read ↗

The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.Semantic proximity Read ↗

Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population.Semantic proximity Read ↗

Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4.Semantic proximity Read ↗

Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults.Semantic proximity Read ↗

Genetic polymorphism of the human ICOS gene.Semantic proximity Read ↗

Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in cytotoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians.Semantic proximity Read ↗

ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study.Semantic proximity Read ↗

Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians.Semantic proximity Read ↗

Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.Semantic proximity Read ↗

ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution.Semantic proximity Read ↗

Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes.Semantic proximity Read ↗

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