Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DRB1 genes and the expression dynamics of HLA CIITA determine the susceptibility to T2DM.

Immunogenetics - 1 Aug 2021

Chinniah Rathika, Sevak Vandit, Pandi Sasiharan, Ravi Padma Malini, Vijayan Murali, Kannan Arun, Karuppiah Balakrishnan

Abstract excerpt

Type 2 diabetes mellitus (T2DM) is a disease with polygenic inheritance. The expression of major histocompatibility complex class II genes are regulated by several trans-activators. We have studied the expression of HLA-DRB1, RFX, CIITA-P1, PIV transactivators, immunophenotyping of cells, SNPs in CIITA-168 (A/G) and IFN-γ + 874 (T/A) in T2DM patients and controls (n = 201 each). We observed increased frequencies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HLA-DRB1 Chains

Share to Nuclear Proteins

Share to Polymorphism, Single Nucleotide

Share to Trans-Activators

Source

Identifiers

PMID: 33754173
DOI: 10.1007/s00251-021-01212-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DRB1 genes and the expression dynamics of HLA CIITA determine the susceptibility to T2DM.PMID 33754173Read ↗

Prevalence of Inflammatory Pathways Over Immuno-Tolerance in Peripheral Blood Mononuclear Cells of Recent-Onset Type 1 DiabetesSemantic proximity Read ↗

The effect of type 1 diabetes protection and susceptibility associated HLA class II genotypes on DNA methylation in immune cells.Semantic proximity Read ↗

Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes.Semantic proximity Read ↗

Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach.Semantic proximity Read ↗

Class II transactivator is required for maximal expression of HLA-DOB in B cells.Semantic proximity Read ↗

Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls.Semantic proximity Read ↗

HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.Semantic proximity Read ↗

A cis-eQTL of HLA-DPB1 Affects Susceptibility to Type 1 Autoimmune Hepatitis.Semantic proximity Read ↗

HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes.Semantic proximity Read ↗

HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients.Semantic proximity Read ↗

Differential expression of transcripts for the autoimmunity-related human dendritic cell immunoreceptor.Semantic proximity Read ↗

Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.