Article
Analysis of CIITA encoding AIR-1 gene promoters in insulin-dependent diabetes mellitus and rheumatoid arthritis patients from the northeast of Italy: absence of sequence variability.
Human immunology - 1 Jun 2000
Sartoris S, Brendolan A, Degola A, Testi M G, Chignola R, Scarpa A, Scardoni M, Contreas G, Pinelli L, Lunardi C, Beri R, Pera C, Ferrara G B, Riviera A P, Tridente G, Andrighetto G
Abstract excerpt
Qualitative and/or quantitative alterations in the expression of the MHC class II molecules affect the onset and maintenance of the immune response and may be the basis of a wide variety of disease states, such as autoimmunity and immunodeficiency.CIITA is a major physiological regulator of the expression of MHC class II genes. The availability of CIITA ap- pears generally essential for MHC class II gene...
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