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Article

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor.

Science (New York, N.Y.) - 23 Feb 1990

Wells A, Welsh J B, Lazar C S, Wiley H S, Gill G N, Rosenfeld M G

Abstract excerpt

Identification of a mutant epidermal growth factor (EGF) receptor that does not undergo downregulation has provided a genetic probe to investigate the role of internalization in ligand-induced mitogenesis. Contact-inhibited cells expressing this internalization-defective receptor exhibited a normal mitogenic response at significantly lower ligand concentrations than did cells expressing wild-type receptors. A...

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Source

Identifiers

PMID: 2305263
DOI: 10.1126/science.2305263

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ligand-induced transformation by a noninternalizing epidermal growth factor receptor.PMID 2305263Read ↗

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Regulation of EGF receptor expression and function.Semantic proximity Read ↗

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Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.Semantic proximity Read ↗

A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells.Semantic proximity Read ↗

Ligand activation of overexpressed epidermal growth factor receptor results in loss of epithelial phenotype and impaired RGD-sensitive integrin function in HSC-1 cells.Semantic proximity Read ↗

Phenotypic transformation of normal rat kidney cells: a model for studying cellular alterations in oncogenesis.Semantic proximity Read ↗

Stimulation of mitogenic pathways through kinase-impaired mutants of the epidermal growth factor receptor.Semantic proximity Read ↗

Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor.Semantic proximity Read ↗

Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.Semantic proximity Read ↗

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