Article
Ligand-induced transformation by a noninternalizing epidermal growth factor receptor.
Science (New York, N.Y.) - 23 Feb 1990
Wells A, Welsh J B, Lazar C S, Wiley H S, Gill G N, Rosenfeld M G
Abstract excerpt
Identification of a mutant epidermal growth factor (EGF) receptor that does not undergo downregulation has provided a genetic probe to investigate the role of internalization in ligand-induced mitogenesis. Contact-inhibited cells expressing this internalization-defective receptor exhibited a normal mitogenic response at significantly lower ligand concentrations than did cells expressing wild-type receptors. A...
Topics
- Cell Division
- Cell Line
- Down-Regulation
- Endocytosis
- Enzyme Activation
- Epidermal Growth Factor
- ErbB Receptors
- Genetic Vectors
- Moloney murine leukemia virus
- Mutation
- Phenotype