Article
Augmented desensitization to epidermal growth factor (EGF) immediate actions: a novel mechanism for altered EGF growth response in mutant A431 cells.
Journal of cellular physiology - 1 Feb 1990
Karasik A, Reddy S S, Pepinsky R B, Brock T, Kahn C R
Abstract excerpt
Epidermal growth factor (EGF) may either stimulate or inhibit cell growth. To elucidate the mechanism of these varied effects, we compared EGF action in parental A431 cells in which cell growth is inhibited, and clone 15, a mutant of these cells resistant to EGF growth inhibition. In both lines,...
Topics
- Annexins
- Calcium
- Calcium-Binding Proteins
- Carcinoma, Squamous Cell
- Cell Division
- Cytoplasm
- Drug Tolerance
- Epidermal Growth Factor
- ErbB Receptors
- Humans
- Mutation
- Phosphorylation
- Phosphotyrosine
- Tumor Cells, Cultured
- Tyrosine