Ligand activation of overexpressed epidermal growth factor receptor results in loss of epithelial phenotype and impaired RGD-sensitive integrin function in HSC-1 cells.

doi:10.1111/1523-1747.ep12329606

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Article

Ligand activation of overexpressed epidermal growth factor receptor results in loss of epithelial phenotype and impaired RGD-sensitive integrin function in HSC-1 cells.

The Journal of investigative dermatology - 1 Aug 1996

Fujii K

Abstract excerpt

Various human carcinomas overexpress epidermal growth factor receptor, and the degree of the expression correlates with their malignant phenotype. Because phenotypic transformation of cells involves qualitative and quantitative alteration of integrin function, we compared the effects of exogenous...

Topics

Down-Regulation
Epidermal Growth Factor
Epithelium
ErbB Receptors
Humans
Integrin beta1
Integrins
Ligands
Oligopeptides
Phenotype
Phosphorylation
Tumor Cells, Cultured
Tyrosine

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