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Article

Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture.

Scientific reports - 1 Jan 2012

Feng Youjun, Cao Min, Shi Jie, Zhang Huimin, Hu Dan, Zhu Jing, Zhang Xianyun, Geng Meiling, Zheng Feng, Pan Xiuzhen, Li Xianfu, Hu Fuquan, Tang Jiaqi, Wang Changjun

Abstract excerpt

NeuB, a sialic acid synthase catalyzes the last committed step of the de novo biosynthetic pathway of sialic acid, a major element of bacterial surface structure. Here we report a functional NeuB homologue of Streptococcus suis, a zoonotic agent, and systematically address its molecular and immunological role in bacterial virulence. Disruption of neuB led to thinner capsules and more susceptibility to pH, and...

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Identifiers

PMID: 23050094
DOI: 10.1038/srep00710
PMCID: PMC3464449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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