Article
Sialylation of lipooligosaccharides is dispensable for the virulence of Haemophilus ducreyi in humans.
Infection and immunity - 1 Feb 2012
Spinola Stanley M, Li Wei, Fortney Kate R, Janowicz Diane M, Zwickl Beth, Katz Barry P, Munson Robert S
Abstract excerpt
Sialylated glycoconjugates on the surfaces of mammalian cells play important roles in intercellular communication and self-recognition. The sialic acid preferentially expressed in human tissues is N-acetylneuraminic acid (Neu5Ac). In a process called molecular mimicry, many bacterial pathogens decorate their cell surface glycolipids with Neu5Ac. Incorporation of Neu5Ac into bacterial glycolipids promotes...
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